Earlier Packard research showed that overexpression of glutamate transporters in mouse models delays onset of symptoms and extends life. More recent Center-assisted studies showed that beta-lactam antibiotics – they boost transporter numbers – also delays disease onset, slows its progression and prolongs life.
Another paper talked about calcium:
"There is a fair amount of evidence that calcium homeostasis is altered in ALS, more speciifically 75% in sALS but not FALS, and that low levels of the calcium binding proteins parvalbumin and calbindin-D28K contribute to selective vulnerability by decreasing the ability of motor neurons to handle an increased calcium load, with cell injury and death as the consequence."
Threonine is good for collagen, elastin and muscle tissue and a study showed upping some amino acids can help with some of the problems.